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KMID : 1037820140030010022
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Journal of Pain and Autonomic Disorders
2014 Volume.3 No. 1 p.22 ~ p.27
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Fibromyalgia in Neurological Pers
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Seok Hung-Youl
Kim Byung-Jo
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Abstract
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Fibromyalgia is a syndrome characterized by chronic widespread pain with multiple tender points, diffuse stiffness, and systemic symptoms such as, depression, insomnia, irritable bowel syndrome, fatigue, and headache without a well-defined underlying organic disease. Central sensitization, which is the consequence of spontaneous nerve activity, enlarged receptive fields, and augmented stimulus responses transmitted by primary afferent fibers, is considered the main mechanism involved and it is defined by the increased response to stimulation mediated by central nervous system signaling. In addition, descending inhibitory pain pathways, which modulate spinal cord responses to painful stimuli, seem to be impaired in patients with fibromyalgia, helping to exacerbate the central sensitization. This paper is primarily intended to suggest pathomechanism of fibromyalgia in perspective of dysfunction of nervous system.
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KEYWORD
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Fibromyalgia, Central sensitization, Pathomechanism
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